Sebaceous adenoma sa is a rare solitary tumour with a predilection for the forehead and scalp. Simple approach to histological diagnosis of common skin. Sebaceous hamartoma on the contrary represents a non neoplastic possibly congenital malformation skin lesion characterized by proliferation of hypertrophic gland lobules and is considered a variant of the fibroadnexal hamartoma. Sebaceous gland tumors are among the most common skin tumors in the dog, accounting for 6. Sebaceous glands within lymphoid tissue key feature. May 14, 2007 histopathology skin sebaceous hyperplasia. Sebaceoma belongs to the group of benign sebaceous tumours.
In addition, their presence in the oral cavity has been described. Sebaceous carcinoma of the eyelid moffitt cancer center. Hyperplasia of sebaceous lobules with expasion of germinative basaloid cell layers at periphery. Benign hyperplasia of sebaceous lobules accompanied by. The inner portions of sebaceous glands are composed of mature sebocytescells with a centrallylocated, often scalloped or indented nucleus and multivacuolated cytoplasm due to the accumulation of lipid secretions. Sebaceous adenomas of the eyelid and muirtorre syndrome. Histology of sebaceoma scanning power of the histology of sebaceoma demonstrates a relatively well circumscribed tumour nodule typically within the deep dermis frequently with attachment to the epidermis.
The histopathologic spectrum of sebaceous neoplasia includes sebaceous adenoma. This is a pdf file of an unedited manuscript that has. Sebaceous gland tumor an overview sciencedirect topics. Sebaceous gland tumours are rare and their presence should be considered as a marker for muirtorre syndrome, alerting to search for an occult malignancy. Pagetoid invasion of the overlying epidermis may be seen. Sebocrine adenoma an adnexal adenoma with sebaceous and. From 1996 to 2012, only six sebaceous adenomas were diagnosed at the henry c. A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8yearold female spayed dog. Cutaneous sebaceous neoplasms show a predilection for the head and neck area of adults and include tumours with benign behaviour, sebaceous adenoma and sebaceoma, and sebaceous carcinoma with potential for an aggressive disease course at the malignant end of the spectrum. In most cases of muirtorre syndrome, the sebaceous neoplasms and associated viscera malignancies are due to abnormalities of mismatch repair proteins. The sebaceous gland is responsible for producing a lubricating oil called sebum, and this may be seen leaking from the mass. There is most often only one, and it is usually found on the face, scalp, belly, back, or chest.
Sweat gland, hair follicle, and sebaceous gland tumors. Aug 15, 2008 sebaceous gland tumours are rare and their presence should be considered as a marker for muirtorre syndrome, alerting to search for an occult malignancy. Sebaceous adenomas can appear as single or multiple tumors. According to our registry, unlike sc, sebaceous adenomas. Sebaceous adenoma is a benign tumor of the sebaceous gland occurring on the skin. The majority of salivary gland neoplasms are benign, with malignant. This tumour is comprised of predominantly sebaceous lobules with a rim of basaloid germinative cells. Muirtorre syndrome is an autosomaldominant disease associated with multiple keratoacanthomas and visceral malignancies, especially genitourinary and gastrointestinal. Sebaceous adenoma in dogs tends to occur later in the pets life i. Matrical carcionoma and sebaceous gland adenocarcinoma are rare and more aggressive forms of the disease. Immunohistochemical staining of normal eyelid tissue and various periorbital epithelial neoplasms. Whether or not true adenoma of sebaceous glands exists is still an unsettled question.
Occasionally they ulcerate and bleed or become tender. Sebaceous adenomas, in isolation, are not significant. Sebaceous hamartoma on the contrary represents a non neoplastic possibly congenital malformation skin lesion characterized by proliferation of hypertrophic gland lobules and is considered a variant of the fibro. Muirtorre syndrome is most frequently caused by mutational. Histopathology adenoma is a benign tumor of glandular tissue, such as the mucosa of stomach, small intestine, and colon, in which tumor cells form glands or gland like structures. Pdf tumors of the salivary glands constitute an important field of oral and maxillofacial pathology. Such bumps are harmless in most cases, and often found on the face. In hollow organs digestive tract, the adenoma grows into the lumen adenomatous polyp or polypoid adenoma. Unrelated to adenoma sebaceum facial angiofibromas of tuberous sclerosis associated with muirtorre syndrome histopathology 2010.
Update on the pathology, genetics and somatic landscape of. Aug 05, 2019 sebaceous adenoma is defined as a benign epithelial neoplasm composed of sebaceous glandlike structures or tumors with wellrecognized sebaceous differentiation by microscopic examination. Main features of sebaceous cell carcinoma cases at the henry c. Sebaceous gland hyperplasia and sebaceous gland adenoma are benign tumors. Among the benign processes, the health care professional should consider sebaceous adenoma, 14 follicular adnexal tumors eg, desmoplastic trichoepithe.
Sebaceous adenomas in these patients often show high degree of microsatellite instability. A sebaceous adenoma, a type of adenoma, a cutaneous condition characterized by a slowgrowing tumor usually presenting as a pink, fleshcoloured, or yellow papule or nodule. Skin adnexal tumors in plain language archives of pathology. Backgroundaims sebaceous adenomas sas are rare, benign sebaceous gland tumours of the eyelid. Sebaceous carcinoma of the eyelid is commonly misdiagnosed because it simulates other entities both clinically and pathologically. Witelson ocular pathology laboratory, when compared to 38 sc. While often recognizable on morphologic grounds alone, sebaceous. Basaloid cells are limited to 1 to 2 layers at the periphery of. Most adnexal neoplasms are uncommonly encountered in routine practice, and pathologists can recognize a limited number of frequently encountered tumors. They are considered low grade malignancies that appear as yellow to pink colored, mushroom shaped, masses on. Distinction of benign sebaceous proliferations from sebaceous. Case report a 60yearold man presented with a mass on the right parotid area that had been gradually enlarging for three years without symptoms of pain or tenderness. Sebaceous gland adenoma and hamartoma in a scottish terrier. Sebaceoma belongs to the group of benign sebaceous tumours histology of sebaceoma.
Further investigations revealed multiple intraabdominal malignancies. Sebaceoma sebaceous epithelioma dermatology advisor. Dec 10, 2019 cutaneous sebaceous neoplasms show a predilection for the head and neck area of adults and include tumours with benign behaviour, sebaceous adenoma and sebaceoma, and sebaceous carcinoma with potential for an aggressive disease course at the malignant end of the spectrum. Sebaceous adenoma arising within an ovarian mature cystic teratoma in muirtorre syndrome. Scanning power of the histology of sebaceoma demonstrates a relatively wellcircumscribed tumour nodule typically within the deep dermis frequently with attachment to the epidermis. Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma. Diagnostics, new delhi, india introduction sebaceous adenoma is an exceptional, distinctive, benign, epithelial neoplasm with sebaceous differentiation. Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry. Numerous islands, ductlike structures, and small to mediumsized cysts are composed of basaloid. Sebaceous adenoma is defined as a benign epithelial neoplasm composed of sebaceous glandlike structures or tumors with wellrecognized sebaceous differentiation by microscopic examination.
If you have several small bumps of the sebaceous glands, this is called sebaceous hyperplasia. Simple approach to histological diagnosis of common skin adnexal tumors ahmed a alhumidi department of pathology, college of medicine, king saud university, riyadh, saudi arabia abstract. A 43yearold caucasian female patient underwent excision of a sebaceous cyst. Tumors of the salivary glands constitute an important field of oral and maxillofacial pathology. It is also linked to hereditary nonpolyposis colorectal cancer lynch syndrome it is not the same as adenoma sebaceum by f. This report presents the ct findings of a cystic sebaceous adenoma in the parotid gland of a 60yearold patient. Sebaceous adenoma is a superficial dermal tumor which differs from sebaceous carcinoma by the lack of significant atypia andor infiltrating growth prognosis and treatment. The purpose of this study was to approximate the prevalence of sas, to determine the reliability of the clinical diagnosis of sas and to demonstrate immunohistochemical. Sebaceous adenoma of the parotid gland scielo espana. The apocrine differentiation is characterized by eccrine poromalike histology. On this basis adenoma sebaceum pringle and senile sebaceous adenoma are generally no longer considered adenomas.
Sebaceous adenoma was initially defined by van walbeek in 1949 1. Sebaceous adenoma results from skin glands that produce skin oils. Normal eyelid tissue and 1 case each of sebaceous carcinoma patient 5, basal cell carcinoma patient 12, and squamous cell carcinoma patient 37 were stained with antikeratin ae1ae3, antiepithelial membrane antigen ema, antibca225 brst1, and antilow molecular. Regardless of the type sweat, hair, or sebaceous diagnosis is made by fine needle aspiration, biopsy, andor initial surgical removal and histopathology. Authors of recent articles are almost unanimously in agreement that adenoma sebaceum pringle represents an organic nevus. Sebaceous adenomas are benign sebaceous tumours that clinically appear as tan. Sebaceous gland adenomas are slowgrowing, benign cutaneous neoplasms involving the gland or duct structures of the oilproducing sebaceous gland that resides in mammalian skin. Small erythematous papules on the nose and cheeks of a child representing angiofibromata.
It is usually a small bump that is normally seen either on the face, scalp, back or chest. Apr 01, 2008 sebaceous adenoma is a benign neoplasm whose origin is from gland structures simple adenoma or ducts and glands compound adenoma. Sebaceous adenomas range from less than 1 cm usually 24 mm to greater than 5 cm in maximum dimension. Sebaceous gland adenoma and hamartoma in a scottish. Sebaceous tumours include hyperplasia, adenoma, sebaceoma and carcinoma. Sebaceous adenoma is a benign tumor affecting the dogs skin. Pdf fibroepithelial polyp with sebaceous hyperplasia. The sebaceous differentiation is characterized by solitary instances or clusters of sebocytes and sebaceous ducts. Sebaceous adenoma is a benign neoplasm whose origin is from gland structures simple adenoma or ducts and glands compound adenoma. The histology of sebaceoma differs from that of sebaceous adenoma in that. Generally the number of sebocytes with vacuolated cytoplasm and scalloped nucleus predominates over the number of basaloid cells, similar to those seen at the periphery of normal sebaceous lobules.
The veterinary pathologist usually adds a prognosis that describ es the probability of local recurrence or metastasis distant spread of the tumor. The histopathologic spectrum of sebaceous neoplasia includes sebaceous adenoma, sebaceoma, and sebaceous carcinoma, while sebaceous hyperplasia represents hyperplasia of benign sebaceous glands surrounding a hair follicle. Sometimes sebaceous adenoma can be seen to arise in a background of surrounding prominent sebaceous glands, suggestive of sebaceous hyperplasia, but as these lesions arise on the face with a significant background of sebaceous glands, this is a difficult determination and an aetiological progression from sebaceous hyperplasia appears unlikely. Similar tumor arising in a benign mixed tumor has only been reported once. In the english literature, less than 10 cases of sa have been described in the oral cavity. The sheets of basaloid cells will demonstrate areas of palisading and clefting typical of basal cell carcinoma in some. Pdf basal cell carcinoma with sebaceous differentiation. Sebaceous adenomas are benign, lobular, organoid tumours showing sebaceous differentiation. Sebaceous adenoma causes, symptoms, treatment, pictures. Carcinoma ex pleomorphic adenoma with sebaceous differentiation in the mandibular salivary gland of a dog o.
Sebaceous adenoma an overview sciencedirect topics. Juliana marquesdacosta1, md, gabriella camposdocarmo1, md, patricia ormiga1. Sebocrine adenoma is a benign cutaneous adnexal neoplasm differentiating in the direction of sebaceous and apocrine glands. Histopathology will give your veterinarian the diagnosis that helps to indicate how the tumor is likely to behave. Immunohistochemical distinction of ocular sebaceous. A 59yearold japanese woman with a sebaceous adenoma on the chest and sebaceous epithelioma on the cheek and mt is presented.
Sebaceous adenomas are usually solid or cystic lesions, characterized by a wellcircumscribed dermal growth of welldifferentiated sebaceous lobules fig. In sebaceous carcinoma, the tumour is generally dermally based with invasion into subcutis figure 1 and native structures. Well differentiated sebaceous carcinoma is a controversial entity. These are painless, slowgrowing tumors that occur in the 4th decade of ones life the cause of the condition is due to sun damage of skin, and hence, any occupation that increases ones exposure to the direct sun may be a risk factor. Less common associations include tumors of the breast and lung. A normal sebaceous lobule a, a sebaceous adenoma b, and a sebaceoma c. Sas may be associated with primary internal malignancies. Sebaceous adenoma is an exceptional, distinctive, benign, epithelial neoplasm.
Basal cell carcinoma with sebaceous differentiation. Pathology of sebaceous hyperplasia dr sampurna roy md. Tumors with sebaceous differentiation represent a challenge to diagnose, classify and occasionally to treat. Sebaceous adenomas range from less than 1 cm usually 2. Surgical removal of sebaceous adenomasebaceoma is curative. The sebaceous adenoma is an uncommon benign tumor which usually presents as a slowly growing, pink or fleshcolored solitary nodule, predominantly on the head and neck of older individuals. These tumors will appear as dome shaped masses with a yellow or pearly white color and are similar in macroscopic appearance to nodular sebaceous hyperplasia. Sebaceous adenoma is a disease in the sebaceous gland or oilproducing gland that has a noncancerous tumor. If this is true, as some have claimed, then it would follow that their immunophenotypes should be identical. Distinction of benign sebaceous proliferations from. Skin gland, hair follicle, and sebaceous gland tumors are more commonly found to be benign. Eruptive sebaceous hyperplasia in association with chronic renal failure.
1444 1368 1117 797 1078 1469 1078 476 830 966 1216 1444 383 885 1402 569 765 820 1449 457 796 221 799 40 565 632 526 854 1261 883 455 1389 358 944 638 17 1073 1434 199 204 1255 86 763 106 1344 283